Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia

Background: Preeclampsia is a highly prevalent disease among pregnant women. In the event of hypertensive emergency, nifedipine, labetalol, and hydralazine are assigned as first-line therapies in preeclampsia. Further studies needed to compare effectiveness these drugs find most cost-effective drug with minimal side effects. This study aimed lowering blood pressure during emergencies severe preeclampsia. Methods: 60 women preeclampsia were recruited this multiple centre double-blind randomized clinical trial from May 2021 April 2022 Indonesia. The patients divided equally into three groups treated doses hydralazine, respectively within one hour 20 minutes interval. was measured based on systolic diastolic pressures, mean arterial (MAP). observation carried out until five hours post-third dose administration. Results: reduced significantly after administration first third each antihypertensive (p<0.05). A single administration, four, one, had 20% MAP reduction group. Three, seven, patient failure reaching even receiving dose. achieve could be ranked follows: nifedipine>labetalol>hydralazine (57.49%, 42.13%, 40.87%, respectively) for hydralazine>nifedipine>labetalol (111.3%, 85.12%, 90.04%, triple dose. Conclusions: Nifedipine effective reduce when used, but requires more further pressure. Hydralazine maxed up interval. Thai Clinical Trials Registry (TCTR): TCTR20221014007 (14/10/2022)